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Article

Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil.

Memorias do Instituto Oswaldo Cruz - 14 May 2018

Alvarado-Arnez Lucia Elena, Batista Angelica Martins, Alves Silvia Marinho, Melo Gloria, Lorena Virgínia Maria Barros de, Cardoso Cynthia C, Pereira Isabela Resende, Carrazzone Cristina, Pacheco Antonio G, Oliveira Wilson, Moraes Milton Ozório, Lannes-Vieira Joseli

Abstract excerpt

BACKGROUND: The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic...

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Identifiers

PMID: 29768622
DOI: 10.1590/0074-02760170489
PMCID: PMC5961924

Genes

TNF
IFNG
LTA

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