Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the gene for lymphotoxin-alpha predispose to chronic Chagas cardiomyopathy.

The Journal of infectious diseases - 15 Dec 2007

Ramasawmy Rajendranath, Fae Kellen C, Cunha-Neto Edecio, Müller Natalie G, Cavalcanti Vanessa L, Ferreira Renata C, Drigo Sandra A, Ianni Barbara, Mady Charles, Goldberg Anna C, Kalil Jorge

Abstract excerpt

BACKGROUND: Chagas disease, caused by Trypanosoma cruzi infection, displays clinical heterogeneity and may be attributable to differential genetic susceptibility. Chronic Chagas cardiomyopathy (CCC) develops only in a subset of T. cruzi-infected individuals and may lead to heart failure that has a worse clinical course and that leads to reduced life expectancy, compared with heart failure of other etiologies....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chagas Cardiomyopathy
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to Lymphotoxin-alpha

Share to Polymorphism, Genetic

Share to Trypanosoma cruzi

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 18190265
DOI: 10.1086/523653

Genes

LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the gene for lymphotoxin-alpha predispose to chronic Chagas cardiomyopathy.PMID 18190265Read ↗

Association between the lymphotoxin-alpha gene polymorphism and chagasic cardiopathy.Semantic proximity Read ↗

Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil.Semantic proximity Read ↗

Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genes.Semantic proximity Read ↗

Lack of association of tumor necrosis factor-alpha polymorphisms with Chagas disease in Brazilian patients.Semantic proximity Read ↗

Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy.Semantic proximity Read ↗

Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways.Semantic proximity Read ↗

Chagas Disease Cardiomyopathy: Immunopathology and GeneticsSemantic proximity Read ↗

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic TargetsSemantic proximity Read ↗

Chagasic cardiomyopathy, from acute to chronic: is this mediated by host susceptibility factors?Semantic proximity Read ↗

The monocyte chemoattractant protein-1 gene polymorphism is associated with cardiomyopathy in human chagas disease.Semantic proximity Read ↗

TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients.Semantic proximity Read ↗

Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.