Article
IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C.
Carcinogenesis - 1 Nov 2009
He Yongchao, Zhang Hongwei, Yin Jianhua, Xie Jiaxin, Tan Xiaojie, Liu Shijian, Zhang Qian, Li Chengzhong, Zhao Jun, Wang Hongyang, Cao Guangwen
Abstract excerpt
Genetic predisposition of nuclear factor-kappa B (NF-kappaB)-signaling pathways linking inflammation to hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remains unresolved. We conducted a case-control study to determine the associations of the polymorphisms within the promoter regions of NFKB1 encoding NF-kappaB1 and NFKBIA encoding IkappaBalpha with the development of HCC. A total of 404 healthy...
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