Article
Functional IL18 polymorphism and susceptibility to Chronic Chagas Disease.
Cytokine - 1 May 2015
Nogueira Luciana Gabriel, Frade Amanda Farage, Ianni Barbara Maria, Laugier Laurie, Pissetti Cristina Wide, Cabantous Sandrine, Baron Monique, Peixoto Gisele de Lima, Borges Ariana de Melo, Donadi Eduardo, Marin-Neto José A, Schmidt André, Dias Fabrício, Saba Bruno, Wang Hui-Tzu Lin, Fragata Abilio, Sampaio Marcelo, Hirata Mario Hiroyuki, Buck Paula, Mady Charles, Martinelli Martino, Lensi Mariana, Siqueira Sergio Freitas, Pereira Alexandre Costa, Rodrigues Virmondes, Kalil Jorge, Chevillard Christophe, Cunha-Neto Edecio
Abstract excerpt
BACKGROUND: Chronic Chagas Disease cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi, the rest of the infected subjects remaining asymptomatic (ASY). The Th1 T cell-rich myocarditis plays a pivotal role in CCC pathogenesis. Local expression of IL-18 in CCC myocardial tissue has recently been described....
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