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Article

Genetic association study of NLRP1, CARD, and CASP1 inflammasome genes with chronic Chagas cardiomyopathy among Trypanosoma cruzi seropositive patients in Bolivia.

PloS one - 1 Jan 2018

Clipman Steven J, Henderson-Frost Josephine, Fu Katherine Y, Bern Caryn, Flores Jorge, Gilman Robert H

Abstract excerpt

About 20-30% of people infected with Chagas disease present with chronic Chagas cardiomyopathy (CCC), the most serious and frequent manifestation of the disease, while others remain asymptomatic and often do not experience Chagas-specific mortality. It is not currently well understood what causes these differential disease outcomes, but a genetic predisposition within the host could play an important role. This...

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Identifiers

PMID: 29438387
DOI: 10.1371/journal.pone.0192378
PMCID: PMC5810984

Genes

NLRP1
CASP1
CARD11

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