Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas' Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy.

doi:10.3389/fimmu.2018.00615

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Article

Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas' Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy.

Frontiers in immunology - 1 Jan 2018

Batista Angelica Martins, Alvarado-Arnez Lucia Elena, Alves Silvia Marinho, Melo Gloria, Pereira Isabela Resende, Ruivo Leonardo Alexandre de Souza, da Silva Andrea Alice, Gibaldi Daniel, da Silva Thayse do E S Protásio, de Lorena Virginia Maria Barros, de Melo Adriene Siqueira, de Araújo Soares Ana Karine, Barros Michelle da Silva, Costa Vláudia Maria Assis, Cardoso Cynthia C, Pacheco Antonio G, Carrazzone Cristina, Oliveira Wilson, Moraes Milton Ozório, Lannes-Vieira Joseli

Abstract excerpt

Chronic cardiomyopathy is the main clinical manifestation of Chagas disease (CD), a disease caused by Trypanosoma cruzi infection. A hallmark of chronic chagasic cardiomyopathy (CCC) is a fibrogenic inflammation mainly composed of CD8+ and CD4+ T cells and macrophages. CC-chemokine ligands and receptors have been proposed to drive cell migration toward the heart tissue of CD patients. Single nucleotide...

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Identifiers

PMID: 29696014
DOI: 10.3389/fimmu.2018.00615
PMCID: PMC5904358

Genes

CCL5
CCR1
CCR5
CCL2
TNF

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