Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways.

doi:10.1186/1471-2334-13-587

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Article

Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways.

BMC infectious diseases - 12 Dec 2013

Frade Amanda Farage, Pissetti Cristina Wide, Ianni Barbara Maria, Saba Bruno, Lin-Wang Hui Tzu, Nogueira Luciana Gabriel, de Melo Borges Ariana, Buck Paula, Dias Fabrício, Baron Monique, Ferreira Ludmila Rodrigues Pinto, Schmidt Andre, Marin-Neto José Antonio, Hirata Mario, Sampaio Marcelo, Fragata Abílio, Pereira Alexandre Costa, Donadi Eduardo, Kalil Jorge, Rodrigues Virmondes, Cunha-Neto Edecio, Chevillard Christophe

Abstract excerpt

BACKGROUND: Chagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America. Thirty percent of infected individuals develop chronic Chagas cardiomyopathy (CCC), an inflammatory dilated cardiomyopathy that is, by far, the most important clinical consequence of T. cruzi infection. The others remain asymptomatic (ASY). A possible genetic component to disease progression was suggested by...

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Identifiers

PMID: 24330528
DOI: 10.1186/1471-2334-13-587
PMCID: PMC3866603

Genes

CCL2
CCR5
MAL
TIRAP

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