Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease.

doi:10.1007/s10875-021-01000-y

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Article

Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease.

Journal of clinical immunology - 1 Jul 2021

Ouarhache Maryem, Marquet Sandrine, Frade Amanda Farage, Ferreira Ariela Mota, Ianni Barbara, Almeida Rafael Ribeiro, Nunes Joao Paulo Silva, Ferreira Ludmila Rodrigues Pinto, Rigaud Vagner Oliveira-Carvalho, Cândido Darlan, Mady Charles, Zaniratto Ricardo Costa Fernandes, Buck Paula, Torres Magali, Gallardo Frederic, Andrieux Pauline, Bydlowsky Sergio, Levy Debora, Abel Laurent, Cardoso Clareci Silva, Santos-Junior Omar Ribeiro, Oliveira Lea Campos, Oliveira Claudia Di Lorenzo, Nunes Maria Do Carmo, Cobat Aurelie, Kalil Jorge, Ribeiro Antonio Luiz, Sabino Ester Cerdeira, Cunha-Neto Edecio, Chevillard Christophe

Abstract excerpt

Cardiomyopathies are an important cause of heart failure and sudden cardiac death. Little is known about the role of rare genetic variants in inflammatory cardiomyopathy. Chronic Chagas disease cardiomyopathy (CCC) is an inflammatory cardiomyopathy prevalent in Latin America, developing in 30% of the 6 million patients chronically infected by the protozoan Trypanosoma cruzi, while 60% remain free of heart disease...

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PMID: 33660144
DOI: 10.1007/s10875-021-01000-y
PMCID: PMC8249271

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