Article
Extinction of alpha 1-antitrypsin gene expression in somatic cell hybrids: evidence for multiple controls.
Genes & development - 1 Feb 1992
Bulla G A, DeSimone V, Cortese R, Fournier R E
Abstract excerpt
Expression of the liver-specific alpha 1-antitrypsin (alpha 1AT) gene is extinguished in hepatoma/fibroblast hybrids. To define the mechanism of extinction, we identified DNA sequences involved in this process by transiently transfecting mutant alpha 1AT promoters into parental and hybrid cells....
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Chloramphenicol O-Acetyltransferase
- DNA-Binding Proteins
- Gene Expression Regulation
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Hybrid Cells
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Rats
- Recombinant Fusion Proteins
- Transcription Factors
- Transcriptional Activation