Article
1,25-Dihydroxyvitamin D3 and transforming growth factor-beta act synergistically to override extinction of liver/bone/kidney alkaline phosphatase in osteosarcoma hybrid cells.
Experimental cell research - 10 Jul 1996
Johnson-Pais T L, Leach R J
Abstract excerpt
In this study, a somatic cell genetic approach was used to study the regulation of liver/bone/kidney alkaline phosphatase (ALPL) gene expression in osteoblasts. ALPL plays an important role in skeletal mineralization and serves as a good index of bone formation. A series of intertypic hybrids con...
Topics
- Alkaline Phosphatase
- Animals
- Base Sequence
- Blotting, Northern
- Bone and Bones
- Calcitriol
- Drug Synergism
- Fibrosarcoma
- Gene Expression Regulation, Enzymologic
- Humans
- Hybrid Cells
- Kidney
- Liver
- Mice
- Molecular Sequence Data
- Osteosarcoma
- Phenotype
- Promoter Regions, Genetic