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Article

Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.

Molecular and cellular biology - 1 Nov 1994

Bulla G A, Fournier R E

Abstract excerpt

A hierarchy of liver-enriched transcription factors plays an important role in activating expression of many hepatic genes. In particular, hepatocyte nuclear factor 4 (HNF-4) is a major activator of the gene encoding HNF-1, and HNF-1 itself activates expression of more than 20 liver genes. To dissect this activation pathway genetically, we prepared somatic cell variants that were deficient in expression of the...

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Identifiers

PMID: 7935424
DOI: 10.1128/mcb.14.11.7086-7094.1994
PMCID: PMC359242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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