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Article

Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants.

Molecular and cellular biology - 1 Nov 1994

Bulla G A, Fournier R E

Abstract excerpt

A hierarchy of liver-enriched transcription factors plays an important role in activating expression of many hepatic genes. In particular, hepatocyte nuclear factor 4 (HNF-4) is a major activator of the gene encoding HNF-1, and HNF-1 itself activates expression of more than 20 liver genes. To dissect this activation pathway genetically, we prepared somatic cell variants that were deficient in expression of the...

Topics

Animals
Base Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
DNA, Neoplasm
DNA-Binding Proteins
Genetic Variation
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha
Hepatocyte Nuclear Factor 1-beta
Hepatocyte Nuclear Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hybrid Cells

Liver Neoplasms, Experimental

Molecular Sequence Data

Mutation

Nuclear Proteins

Phenotype

Phosphoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7935424
DOI: 10.1128/mcb.14.11.7086-7094.1994
PMCID: PMC359242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7935424-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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