Article
Tissue-specific extinguisher loci in the human genome: a screening study based on random marking and transfer of human chromosomes.
Somatic cell and molecular genetics - 1 May 1994
Shapero M H, Langston A A, Fournier R E
Abstract excerpt
Expression of many liver-specific genes is extinguished when cultured hepatoma cells are fused with fibroblasts, but liver genes can be reexpressed in hybrid segregants that have lost fibroblast chromosomes. To map extinguisher loci involved in this process, hepatoma microcell hybrids retaining s...
Topics
- Animals
- Chromosomes, Human, Pair 14
- Clone Cells
- Gene Expression Regulation
- Genetic Markers
- Genome, Human
- Genotype
- Humans
- Hybrid Cells
- Liver
- Liver Neoplasms, Experimental
- Phenotype
- Phosphoenolpyruvate Carboxykinase (GTP)
- RNA, Messenger
- Rats
- Tumor Cells, Cultured