Article
Activation of the galectin-1 (L-14-I) gene from nonexpressing differentiated cells by fusion with undifferentiated and tumorigenic cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1994
Chiariotti L, Benvenuto G, Zarrilli R, Rossi E, Salvatore P, Colantuoni V, Bruni C B
Abstract excerpt
Expression of the galectin-1 (L-14-I) gene, elevated in most differentiated and transformed cell lines, has been studied in cell hybrid systems. Fusion of L-14-I nonproducing rat liver differentiated FAO cells with dedifferentiated rat liver BRL3A cells leads to extinction of liver-specific gene expression while L-14-I mRNA levels remain high. Interspecific hybrids produced by fusion of tumorigenic human...
Topics
- Alleles
- Animals
- Azacitidine
- Base Sequence
- Cell Differentiation
- Cell Fusion
- Cells, Cultured
- Galectin 1
- Gene Expression Regulation, Neoplastic
- Genes, Dominant