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Article

Direct selection of hepatoma cell variants deficient in alpha 1-antitrypsin gene expression.

Somatic cell and molecular genetics - 1 Jul 1992

Bulla G A, Fournier R E

Abstract excerpt

Expression plasmids containing the human alpha 1-antitrypsin (alpha 1 AT) promoter fused to either adenine phosphoribosyltransferase (aprt) or xanthine-guanine phosphoribosyltransferase (gpt) coding sequences were sequentially introduced into APRT- HPRT- rat hepatoma cells. Stable transfectants expressing both transgenes were isolated and characterized. Nonexpressing variants were subsequently obtained by...

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Identifiers

PMID: 1332197
DOI: 10.1007/BF01235759

Genes

APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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