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Article

Extinction of albumin gene expression in a panel of human chromosome 2 microcell hybrids.

Genomics - 1 Feb 1996

Cerosaletti K M, Fournier R E

Abstract excerpt

Expression of the serum albumin gene is extinguished in rat hepatoma microcell hybrids that retain mouse chromosome 1. These data define a trans-dominant extinguisher locus, Tse-2, on mouse chromosome 1. To localize the human TSE2 locus, we prepared and characterized rat/human microcell hybrids that contained either human chromosome 1 or chromosome 2, the genetic homologues of mouse chromosome 1. Rat hepatoma...

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PMID: 8838317
DOI: 10.1006/geno.1996.0058

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