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Article

K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea.

Carcinogenesis - 1 Jan 1992

Jacoby R F, Alexander R J, Raicht R F, Brasitus T A

Abstract excerpt

We have been studying a rat model of colon cancer in which tumors are induced by direct application of N-methyl-N-nitrosourea (MNU) to discrete areas of the colonic mucosa for a limited period of time. Activation of the ras genes by point mutation has been observed in many experimental tumors, in...

Topics

3T3 Cells
Animals
Colonic Neoplasms
DNA, Neoplasm
Gene Expression Regulation
Genes, ras
Male
Methylnitrosourea
Mice
Mutation
Rats
Rats, Inbred F344

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1733572
DOI: 10.1093/carcin/13.1.45

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1733572-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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