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Article

K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea.

Carcinogenesis - 1 Jan 1992

Jacoby R F, Alexander R J, Raicht R F, Brasitus T A

Abstract excerpt

We have been studying a rat model of colon cancer in which tumors are induced by direct application of N-methyl-N-nitrosourea (MNU) to discrete areas of the colonic mucosa for a limited period of time. Activation of the ras genes by point mutation has been observed in many experimental tumors, including tumors induced by MNU. To detect potential activating point mutations in the H-ras and K-ras oncogenes in...

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Identifiers

PMID: 1733572
DOI: 10.1093/carcin/13.1.45

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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