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Article

Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.

Cancer science - 1 Jun 2004

Takahashi Mami, Wakabayashi Keiji

Abstract excerpt

Studies of colon carcinogenesis in animal models are very useful to elucidate mechanisms and provide pointers to potential prevention approaches in the human situation. In the rat colon carcinogenesis model induced by azoxymethane (AOM), we have documented frequent mutations of specific genes. K-ras mutations at codon 12 were found to be frequent in hyperplastic aberrant crypt foci (ACF) and large...

Topics

Animals
Azoxymethane
Colonic Neoplasms
Cyclooxygenase 2
Cytoskeletal Proteins
Gene Expression Regulation
Genes, ras
Humans
Isoenzymes
Membrane Proteins
Mutation
Nitric Oxide Synthase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nitric Oxide Synthase Type II

Prostaglandin-Endoperoxide Synthases

Trans-Activators

beta Catenin

Source

Open in PubMed Open full text

Identifiers

PMID: 15182426
DOI: 10.1111/j.1349-7006.2004.tb03235.x
PMCID: PMC11158569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15182426-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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