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Article

K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.

Carcinogenesis - 1 Sept 1993

Vivona A A, Shpitz B, Medline A, Bruce W R, Hay K, Ward M A, Stern H S, Gallinger S

Abstract excerpt

Ras mutations are an important early event in a number of carcinogen-induced rodent tumors. Colon carcinogenesis induced in rats by azoxymethane is a useful model as it mimics the adenoma-carcinoma sequence observed in humans. In addition, aberrant crypt foci develop in the rat and these lesions appear to be potentially important precursors to adenomas in colorectal cancer. Recent studies have shown that specific...

Topics

Adenocarcinoma
Adenoma
Animals
Azoxymethane
Base Sequence
Blotting, Southern
Colon
Colonic Neoplasms
Female
Genes, ras
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Rats

Rats, Inbred F344

Source

Identifiers

PMID: 8403199
DOI: 10.1093/carcin/14.9.1777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8403199-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.PMID 8403199Read ↗

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