Article
Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis.
Carcinogenesis - 1 Jul 1994
Singh J, Kulkarni N, Kelloff G, Reddy B S
Abstract excerpt
In our previous study, we demonstrated that azoxymethane (AOM) treatment significantly enhanced the expression of ras p21, the protein product of ras genes, and that the dietary administration of chemopreventive agents such as D,L-alpha-difluoromethylornithine (DFMO), a irreversible inhibitor of ornithine decarboxylase, and piroxicam, a non-steroidal anti-inflammatory drug (NSAID), exerted a significant...
Topics
- Animals
- Anticarcinogenic Agents
- Azoxymethane
- Base Sequence
- Colon
- Colonic Neoplasms
- Eflornithine
- Genes, ras
- Intestinal Mucosa
- Male
- Molecular Sequence Data
- Mutation