Article
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Oncogene - 28 Jun 2007
Luo F, Brooks D G, Ye H, Hamoudi R, Poulogiannis G, Patek C E, Winton D J, Arends M J
Abstract excerpt
K-ras mutation occurs in 40-50% of human colorectal adenomas and carcinomas, but its contribution to intestinal tumorigenesis in vivo is unclear. We developed K-ras(V12) transgenic mice that were crossed with Ah-Cre mice to generate K-ras(V12)/Cre mice, which showed beta-naphthoflavone-induction of Cre-mediated LoxP recombination that activated intestinal expression of K-ras(V12) 4A and 4B transcripts and...
Topics
- Animals
- DNA Mismatch Repair
- Genes, ras
- Integrases
- Intestinal Neoplasms
- MAP Kinase Signaling System
- Mice
- Mice, Transgenic
- MutS Homolog 2 Protein
- Mutation
- Proto-Oncogene Proteins c-akt