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Article

Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.

Oncogene - 28 Jun 2007

Luo F, Brooks D G, Ye H, Hamoudi R, Poulogiannis G, Patek C E, Winton D J, Arends M J

Abstract excerpt

K-ras mutation occurs in 40-50% of human colorectal adenomas and carcinomas, but its contribution to intestinal tumorigenesis in vivo is unclear. We developed K-ras(V12) transgenic mice that were crossed with Ah-Cre mice to generate K-ras(V12)/Cre mice, which showed beta-naphthoflavone-induction of Cre-mediated LoxP recombination that activated intestinal expression of K-ras(V12) 4A and 4B transcripts and...

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Identifiers

PMID: 17297472
DOI: 10.1038/sj.onc.1210231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.PMID 17297472Read ↗

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