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Article

Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver.

International journal of cancer - 2 Dec 1991

Oudejans J J, Slebos R J, Zoetmulder F A, Mooi W J, Rodenhuis S

Abstract excerpt

To study the possible role of ras oncogene activation in the dissemination of colon cancer, we determined point mutations in codons 12, 13 and 61 in K- and N-ras in 3 groups of tumors: (A) primary tumors of patients who had undergone surgery for Dukes' B (early-stage) colon cancer, (B) primary tumors and metastases from patients undergoing resection of isolated lung metastases and (C) primary tumors and...

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Source

Identifiers

PMID: 1959991
DOI: 10.1002/ijc.2910490613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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