Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver.

doi:10.1002/ijc.2910490613

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Article

Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver.

International journal of cancer - 2 Dec 1991

Oudejans J J, Slebos R J, Zoetmulder F A, Mooi W J, Rodenhuis S

Abstract excerpt

To study the possible role of ras oncogene activation in the dissemination of colon cancer, we determined point mutations in codons 12, 13 and 61 in K- and N-ras in 3 groups of tumors: (A) primary tumors of patients who had undergone surgery for Dukes' B (early-stage) colon cancer, (B) primary tu...

Topics

Adenocarcinoma
Aged
Codon
Colonic Neoplasms
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Liver Neoplasms
Lung Neoplasms
Male
Middle Aged
Mutation
Neoplasm Staging

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