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Article

K-ras gene mutations in adenomas and carcinomas of the colon.

Surgical oncology - 1 Aug 1992

Boughdady I S, Kinsella A R, Haboubi N Y, Schofield P F

Abstract excerpt

DNA extracted from 29 colorectal carcinomas and 40 sporadic adenomas was amplified by the polymerase chain reaction (PCR) and analysed for the presence of K-ras gene mutations at codon 12 using a panel of synthetic oligonucleotide probes specific for normal and mutated sequences. The presence of mutations was correlated with various histopathological and clinical data. Ten carcinomas (34.5%) and 14 sporadic...

Topics

Adenoma
Adult
Aged
Base Sequence
Carcinoma
Codon
Colonic Neoplasms
Colonic Polyps
DNA
Female
Genes, ras
Humans
Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Source

Identifiers

PMID: 1341261
DOI: 10.1016/0960-7404(92)90088-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1341261-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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