Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.

doi:10.1172/JCI115039

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Article

Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.

The Journal of clinical investigation - 1 Feb 1991

Jacoby R F, Llor X, Teng B B, Davidson N O, Brasitus T A

Abstract excerpt

These experiments were conducted to determine whether point mutations activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic mucosa. Rats were injected weekly with diluent or DMH at 20 mg/kg body wt for 5, 10, 15, or 25 wk, killed, and their colons dissected. DNA was extracted from diluent-injected control animals,...

Topics

1,2-Dimethylhydrazine
Animals
Base Sequence
Cell Transformation, Neoplastic
Codon
Colonic Neoplasms
DNA
Dimethylhydrazines
Genes, ras
Intestinal Mucosa
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Polymerase Chain Reaction

Precancerous Conditions

Rats

Source

Open in PubMed Open full text

Identifiers

PMID: 1991846
DOI: 10.1172/JCI115039
PMCID: PMC296352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1991846-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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