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Article

Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.

The Journal of clinical investigation - 1 Feb 1991

Jacoby R F, Llor X, Teng B B, Davidson N O, Brasitus T A

Abstract excerpt

These experiments were conducted to determine whether point mutations activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic mucosa. Rats were injected weekly with diluent or DMH at 20 mg/kg body wt for 5, 10, 15, or 25 wk, killed, and their colons dissected. DNA was extracted from diluent-injected control animals,...

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Identifiers

PMID: 1991846
DOI: 10.1172/JCI115039
PMCID: PMC296352

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.PMID 1991846Read ↗

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