Ras gene mutation-independent tumours in the intestine of the rat by a single dose of N-methyl-N-nitrosourea.

Article

Ras gene mutation-independent tumours in the intestine of the rat by a single dose of N-methyl-N-nitrosourea.

International journal of experimental pathology - 1 Aug 1992

Waldmann V, Rabes H M

Abstract excerpt

Aiming at a sequential analysis of the role of ras gene point mutations during intestinal carcinogenesis, we established an experimental rat tumour model using N-methyl-N-nitrosourea (MNU) as an initiating agent as this carcinogen has been found to induce rat mammary carcinomas with a high preval...

Topics

Animals
Cell Transformation, Neoplastic
Gene Amplification
Genes, ras
Ileal Neoplasms
Ileum
Intestinal Neoplasms
Jejunal Neoplasms
Jejunum
Male
Methylnitrosourea
Mutation
Rats
Rats, Inbred Strains

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