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Article

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

Gastroenterology - 1 Oct 2017

Joosten Sander P J, Zeilstra Jurrit, van Andel Harmen, Mijnals R Clinton, Zaunbrecher Joost, Duivenvoorden Annet A M, van de Wetering Marc, Clevers Hans, Spaargaren Marcel, Pals Steven T

Abstract excerpt

BACKGROUND & AIMS: Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the receptor for hepatocyte growth factor (HGF). We investigated how MET signaling, and its interaction...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28716720
DOI: 10.1053/j.gastro.2017.07.008

Genes

MET
HGF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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