Article
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
The Journal of pathology - 1 Apr 2010
Luo Feijun, Ye Hongtao, Hamoudi Rifat, Dong Gehong, Zhang Wenyan, Patek Charles E, Poulogiannis George, Arends Mark J
Abstract excerpt
K-ras encodes two isoforms, K-ras 4A and 4B, that are jointly affected by K-ras activating mutations, which are prevalent in colorectal cancer (CRC). CRC shows alterations in the expressed K-ras 4A : 4B isoform ratio in favour of K-ras 4B, in tumours both with and without K-ras mutations. The pre...
Topics
- 1,2-Dimethylhydrazine
- Adenoma
- Animals
- Apoptosis
- Carcinogens
- Cell Proliferation
- Cell Transformation, Neoplastic
- Colonic Neoplasms
- Enzyme Activation
- Exons
- Genes, Tumor Suppressor
- Genes, ras
- MAP Kinase Signaling System
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Proto-Oncogene Proteins c-akt