Article
Msh2 deficiency increases the mutation frequency in all parts of the mouse colon.
Environmental and molecular mutagenesis - 1 Jan 2002
Zhang Shulin, Lloyd Ruth, Bowden Gregory, Glickman Barry W, de Boer Johan G
Abstract excerpt
The Msh2 DNA mismatch repair gene is one of five genes implicated in the pathogenesis of hereditary nonpolyposis colorectal cancer (HNPCC). To address the possible mechanisms of the site-specific occurrence of HNPCC, the effect of Msh2 deficiency on mutations in different parts of the colon was investigated using the BC-1(lacI)/Msh2 double transgenic mouse. Compared to the Msh2(+/+) mice, Msh2(-/-) mice had an...
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