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Article

Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.

Carcinogenesis - 1 Feb 2003

Sohn Kyoung-Jin, Choi Monica, Song Jacquelin, Chan Sofeene, Medline Alan, Gallinger Steven, Kim Young-In

Abstract excerpt

Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the role of Msh2 in post-replicative DNA repair, this study investigated whether Msh2 deficiency...

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PMID: 12584170
DOI: 10.1093/carcin/24.2.217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.PMID 12584170Read ↗

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Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.Semantic proximity Read ↗

The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.Semantic proximity Read ↗

The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.Semantic proximity Read ↗

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.Semantic proximity Read ↗

Msh2 deficiency increases the mutation frequency in all parts of the mouse colon.Semantic proximity Read ↗

Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors.Semantic proximity Read ↗

Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency.Semantic proximity Read ↗

MSH2 deficient mice are viable and susceptible to lymphoid tumours.Semantic proximity Read ↗

Somatic mutational mechanisms involved in intestinal tumor formation in Min mice.Semantic proximity Read ↗

Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.Semantic proximity Read ↗

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