Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

International journal of experimental pathology - 1 Oct 2009

Luo Feijun, Brooks David G, Ye Hongtao, Hamoudi Rifat, Poulogiannis George, Patek Charles E, Winton Douglas J, Arends Mark J

Abstract excerpt

Summary K-ras mutations are found in 40-50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by beta-Naphthoflavone (beta-NF) treatment, displayed transgene recombination and K-ras(Asp12) expression in the murine intestines, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Genes, ras

Share to Intestinal Neoplasms

Share to Intestine, Small

Share to Oncogene Protein p21(ras)

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19765110
DOI: 10.1111/j.1365-2613.2009.00667.x
PMCID: PMC2768154

Genes

MMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.PMID 19765110Read ↗

Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.Semantic proximity Read ↗

Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.Semantic proximity Read ↗

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.Semantic proximity Read ↗

K-Ras, intestinal homeostasis and colon cancer.Semantic proximity Read ↗

APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.Semantic proximity Read ↗

The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.Semantic proximity Read ↗

Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.Semantic proximity Read ↗

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.Semantic proximity Read ↗

Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.Semantic proximity Read ↗

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.Semantic proximity Read ↗

Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.Semantic proximity Read ↗

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal TumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.