Article
Multistep carcinogenesis in colorectal cancers.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 1995
Takami K, Yana I, Kurahashi H, Nishisho I
Abstract excerpt
Recent advances in molecular genetics have revealed that multiple genetic alterations including activation of oncogenes and inactivation of tumor suppressor genes are required for tumor development and progression. Tumorigenesis of colorectal cancer, in which most cancers are considered to arise from preceding benign adenomas, has been well documented at the molecular level. Familial adenomatous polyposis (FAP),...
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