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Article

Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin.

Gastroenterology - 1 Feb 2007

Jung Barbara H, Beck Stayce E, Cabral Jennifer, Chau Eddy, Cabrera Betty L, Fiorino Antonio, Smith E Julieta, Bocanegra Melanie, Carethers John M

Abstract excerpt

BACKGROUND & AIMS: Colon cancers with high-frequency microsatellite instability (MSI-H) develop frameshift mutations in tumor suppressors as part of their pathogenesis. ACVR2 is mutated at its exon 10 polyadenine tract in >80% of MSI-H colon cancers, coinciding with loss of protein. ACVR2 transmits the growth effects of activin via phosphorylation of SMAD proteins to affect gene transcription. The functional...

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Source

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Identifiers

PMID: 17258738
DOI: 10.1053/j.gastro.2006.11.018
PMCID: PMC4154562

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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