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Article

FXR silencing in human colon cancer by DNA methylation and KRAS signaling

1 Nov 2013

Abstract excerpt

Farnesoid X receptor (FXR) is a bile acid nuclear receptor described through mouse knockout studies as a tumor suppressor for the development of colon adenocarcinomas. This study investigates the regulation of FXR in the development of human colon cancer. We used immunohistochemistry of FXR in normal tissue (n = 238), polyps (n = 32), and adenocarcinomas, staged I-IV (n = 43, 39, 68, and 9), of the colon;...

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PMID: 24177031
DOI: 10.1152/ajpgi.00234.2013

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