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Article

Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.

Gastroenterology - 1 Mar 2004

Jung Barbara, Doctolero Ryan T, Tajima Akihiro, Nguyen Alexie K, Keku Temitope, Sandler Robert S, Carethers John M

Abstract excerpt

BACKGROUND & AIMS: Colorectal tumors manifesting high-frequency microsatellite instability (MSI-H) develop genetically as a consequence of mutations in genes harboring repetitive DNA sequences. The activin type 2 receptor (ACVR2), possessing 2 polyadenine coding sequences, was identified as a mutational target, but it is not clear if expression is abrogated. Here, we analyzed MSI-H colorectal cancers for ACVR2...

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Source

Identifiers

PMID: 14988818
DOI: 10.1053/j.gastro.2004.01.008

Genes

TGFBR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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