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Article

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

Cancer research - 15 Jan 1999

Grady W M, Myeroff L L, Swinler S E, Rajput A, Thiagalingam S, Lutterbaugh J D, Neumann A, Brattain M G, Chang J, Kim S J, Kinzler K W, Vogelstein B, Willson J K, Markowitz S

Abstract excerpt

We previously demonstrated that mutational inactivation of transforming growth factor beta type II receptors (RIIs) is very common among the 13% of human colon cancers with microsatellite instability. These mutations principally cluster in the BAT-RII polyadenine sequence repeat. Among microsatel...

Topics

Adult
Colonic Neoplasms
Female
Humans
Male
Microsatellite Repeats
Middle Aged
Mutation
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transforming Growth Factor beta

Tumor Cells, Cultured

Source

Identifiers

PMID: 9927040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927040-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.PMID 9927040Read ↗

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