Article
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.
Cancer research - 15 Jan 1999
Grady W M, Myeroff L L, Swinler S E, Rajput A, Thiagalingam S, Lutterbaugh J D, Neumann A, Brattain M G, Chang J, Kim S J, Kinzler K W, Vogelstein B, Willson J K, Markowitz S
Abstract excerpt
We previously demonstrated that mutational inactivation of transforming growth factor beta type II receptors (RIIs) is very common among the 13% of human colon cancers with microsatellite instability. These mutations principally cluster in the BAT-RII polyadenine sequence repeat. Among microsatellite stable (MSS) colon cancers, we now find that non-BAT-RII point mutations inactivate RII in another 15% of cases,...
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