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Article

Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers

27 Dec 2005

Abstract excerpt

High-frequency microsatellite unstable (MSI-H) colon tumors develop as a consequence of mutations at repetitive sequences in target genes. TGFBR2 and ACVR2, encoding TGFbeta superfamily receptors, and the proapoptotic gene BAX are frequent targets for frameshift mutation. We analyzed the effect of these mutations on survival and histology in 2 separate cohorts. Forty-eight MSI-H Dukes B2 colon tumors from a...

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Identifiers

PMID: 16380996
DOI: 10.1002/ijc.21710

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Source receipt: pubmed, retrieved 7 Sept 2026.

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