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Article

Bone morphogenetic protein signaling and growth suppression in colon cancer

12 Jun 2006

Abstract excerpt

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily, which utilize BMP receptors and intracellular SMADs to transduce their signals to regulate cell differentiation, proliferation, and apoptosis. Because mutations in BMP receptor type IA (BMPRIA) and SMAD4 are found in the germline of patients with the colon cancer predisposition syndrome juvenile polyposis, and...

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PMID: 16769811
DOI: 10.1152/ajpgi.00482.2005

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