Article
Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.
PloS one - 14 Dec 2009
Jung Barbara, Gomez Jessica, Chau Eddy, Cabral Jennifer, Lee Jeffrey K, Anselm Aimee, Slowik Przemyslaw, Ream-Robinson Deena, Messer Karen, Sporn Judith, Shin Sung K, Boland C Richard, Goel Ajay, Carethers John M
Abstract excerpt
BACKGROUND: Activin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon cancers. METHODS: Fifty-one population-based MSS colon cancers were assessed for ACVR1, ACVR2 and pSMAD2 protein. Consensus mutation-prone portions of ACVR2...
Topics
- Activin Receptors, Type I
- Activin Receptors, Type II
- Cell Line, Tumor
- Colonic Neoplasms
- DNA Methylation
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Humans
- Loss of Heterozygosity