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Article

Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

PloS one - 14 Dec 2009

Jung Barbara, Gomez Jessica, Chau Eddy, Cabral Jennifer, Lee Jeffrey K, Anselm Aimee, Slowik Przemyslaw, Ream-Robinson Deena, Messer Karen, Sporn Judith, Shin Sung K, Boland C Richard, Goel Ajay, Carethers John M

Abstract excerpt

BACKGROUND: Activin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon cancers. METHODS: Fifty-one population-based MSS colon cancers were assessed for ACVR1, ACVR2 and pSMAD2 protein. Consensus mutation-prone portions of ACVR2...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20011542
DOI: 10.1371/journal.pone.0008308
PMCID: PMC2789408

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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