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Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Sept 2021

Yuza Kizuki, Nagahashi Masayuki, Ichikawa Hiroshi, Hanyu Takaaki, Nakajima Masato, Shimada Yoshifumi, Ishikawa Takashi, Sakata Jun, Takeuchi Shiho, Okuda Shujiro, Matsuda Yasunobu, Abe Manabu, Sakimura Kenji, Takabe Kazuaki, Wakai Toshifumi

Abstract excerpt

BACKGROUND: Activin A receptor type 2A (ACVR2A) is one of the most frequently mutated genes in microsatellite instability-high (MSI-H) gastric cancer. However, the clinical relevance of the ACVR2A mutation in MSI-H gastric cancer patients remains unclear. The aims of this study were to explore the effect of ACVR2A mutation on the tumor behavior and to identify the clinicopathological characteristics of gastric...

Topics

Activin Receptors, Type II
Activins
Aged
Biology
Humans
Microsatellite Instability
Mutation
Retrospective Studies
Stomach Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33420656
DOI: 10.1007/s11605-020-04889-9
PMCID: PMC8728635

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