Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.

Gastroenterology - 1 May 2008

Kodach Liudmila L, Wiercinska Eliza, de Miranda Noel F C C, Bleuming Sylvia A, Musler Alex R, Peppelenbosch Maikel P, Dekker Evelien, van den Brink Gijs R, van Noesel Carel J M, Morreau Hans, Hommes Daniel W, Ten Dijke Peter, Offerhaus G Johan A, Hardwick James C H

Abstract excerpt

BACKGROUND & AIMS: The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC. METHODS: We investigated BMP receptor (BMPR) expression using immunoblotting and sequenced BMPR2 in CRC cell lines. We assessed the expression of BMPRs, SMAD4, and pSMAD1/5/8 in 72 sporadic CRCs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 2
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Immunoblotting

Share to Microsatellite Instability

Share to RNA, Neoplasm

Share to Smad4 Protein

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 18471510
DOI: 10.1053/j.gastro.2008.02.059

Genes

BMPR2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.PMID 18471510Read ↗

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancerSemantic proximity Read ↗

Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based studySemantic proximity Read ↗

Somatic alterations in juvenile polyps from BMPR1A and SMAD4 mutation carriers.Semantic proximity Read ↗

BMPR2 as a Novel Predisposition Gene for Hereditary Colorectal Polyposis.Semantic proximity Read ↗

Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis.Semantic proximity Read ↗

Somatic frameshift mutations of bone morphogenic protein receptor 2 gene in gastric and colorectal cancers with microsatellite instability.Semantic proximity Read ↗

The rate of germline mutations and large deletions of <i>SMAD4 </i>and <i>BMPR1A </i>in juvenile polyposisSemantic proximity Read ↗

The prevalence of <i>MADH4</i> and <i>BMPR1A</i> mutations in juvenile polyposis and absence of <i>BMPR2</i>, <i>BMPR1B</i>, and <i>ACVR1</i> mutationsSemantic proximity Read ↗

Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.Semantic proximity Read ↗

Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formationSemantic proximity Read ↗

Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.Semantic proximity Read ↗

Bone morphogenetic protein signaling and growth suppression in colon cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.