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Article

Enhancement of TGF-β signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer.

Cancer research - 15 Oct 2011

Sharma Vikas, Antonacopoulou Anna G, Tanaka Shinya, Panoutsopoulos Alexios A, Bravou Vasiliki, Kalofonos Haralabos P, Episkopou Vasso

Abstract excerpt

TGF-β signaling provides tumor protection against colorectal cancer (CRC). Mechanisms that support its tumor-suppressive properties remain unclear. The ubiquitin ligase Arkadia/RNF111 enhances TGF-β signaling responses by targeting repressors of the pathway for degradation. The corepressors SnoN/Ski, critical substrates of Arkadia, complex with the activated TGF-β signaling effectors Smad2/3 (pSmad2/3) on the...

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Identifiers

PMID: 21998011
DOI: 10.1158/0008-5472.CAN-11-1645
PMCID: PMC3194767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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