Article
Enhancement of TGF-β signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer.
Cancer research - 15 Oct 2011
Sharma Vikas, Antonacopoulou Anna G, Tanaka Shinya, Panoutsopoulos Alexios A, Bravou Vasiliki, Kalofonos Haralabos P, Episkopou Vasso
Abstract excerpt
TGF-β signaling provides tumor protection against colorectal cancer (CRC). Mechanisms that support its tumor-suppressive properties remain unclear. The ubiquitin ligase Arkadia/RNF111 enhances TGF-β signaling responses by targeting repressors of the pathway for degradation. The corepressors SnoN/Ski, critical substrates of Arkadia, complex with the activated TGF-β signaling effectors Smad2/3 (pSmad2/3) on the...
Topics
- Adenocarcinoma
- Amino Acid Sequence
- Animals
- Azoxymethane
- Base Sequence
- Colon
- Colorectal Neoplasms
- Gene Expression Regulation, Neoplastic
- HEK293 Cells
- Humans
- Intracellular Signaling Peptides and Proteins
- Mice
- Molecular Sequence Data