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Article

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.

International journal of cancer - 1 Feb 2006

Grady William M, Willis Joseph E, Trobridge Patty, Romero-Gallo Judith, Munoz Nina, Olechnowicz Joseph, Ferguson Kelly, Gautam Shiva, Markowitz Sanford D

Abstract excerpt

Approximately 15% of human colon cancers have microsatellite instability (MSI) and carry frameshift mutations in a polyadenine tract (BAT-RII) in the type II transforming growth factor beta (TGF-beta) receptor (TGFBR2), a required component of the TGF-beta receptor. The BAT-RII mutations in MSI colon cancers make the tumors resistant to the effects of TGF-beta. In cultured epithelial cells, TGF-beta can inhibit...

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Source

Identifiers

PMID: 16108056
DOI: 10.1002/ijc.21399

Genes

TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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