Article
Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.
Gastroenterology - 1 Jun 2015
de Miranda Noel F C C, van Dinther Maarten, van den Akker Brendy E W M, van Wezel Tom, ten Dijke Peter, Morreau Hans
Abstract excerpt
BACKGROUND & AIMS: Most colorectal cancer (CRC) cells with high levels of microsatellite instability (MSI-H) accumulate mutations at a microsatellite sequence in the gene encoding transforming growth factor β receptor II (TGFBR2). TGFβ signaling therefore is believed to be defective in these tumors, although CRC cells with TGFBR2 mutations have been reported to remain sensitive to TGFβ. We investigated how TGFβ...
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