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Article

Sirtuin‐independent effects of nicotinamide on lifespan extension from calorie restriction in yeast

20 Oct 2006

Abstract excerpt

Two models have been proposed for how calorie restriction (CR) enhances replicative longevity in yeast: (i) suppression of rDNA recombination through activation of the sirtuin protein deacetylase Sir2 or (ii) decreased activity of the nutrient-responsive kinases Sch9 and TOR. We report here that CR increases lifespan independently of all Sir2-family proteins in yeast. Furthermore, we demonstrate that...

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Identifiers

PMID: 17129213
DOI: 10.1111/j.1474-9726.2006.00240.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sirtuin‐independent effects of nicotinamide on lifespan extension from calorie restriction in yeastPMID 17129213Read ↗

HST2 mediates SIR2-independent life-span extension by calorie restriction.Semantic proximity Read ↗

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.Semantic proximity Read ↗

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A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sir2 blocks extreme life-span extension.Semantic proximity Read ↗

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Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.Semantic proximity Read ↗

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