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The Sir2 Family of Protein Deacetylases

1 Jun 2004

Abstract excerpt

The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging from archaea to humans. Interestingly, Sir2 is active as an NAD+-dependent deacetylase, which is broadly conserved from bacteria to...

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PMID: 15189148
DOI: 10.1146/annurev.biochem.73.011303.073651

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