Article
HST2 mediates SIR2-independent life-span extension by calorie restriction.
Science (New York, N.Y.) - 16 Sept 2005
Lamming Dudley W, Latorre-Esteves Magda, Medvedik Oliver, Wong Stacy N, Tsang Felicia A, Wang Chen, Lin Su-Ju, Sinclair David A
Abstract excerpt
Calorie restriction (CR) extends the life span of numerous species, from yeast to rodents. Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD+-dependent histone deacetylase that has been proposed to mediate the effects of CR. However, this hypothesis has been challenged by the observation that CR can extend yeast life span in the absence of Sir2. Here, we show that Sir2-independent life-span extension is...
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