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Article

Sir2-independent life span extension by calorie restriction in yeast.

PLoS biology - 1 Sept 2004

Kaeberlein Matt, Kirkland Kathryn T, Fields Stanley, Kennedy Brian K

Abstract excerpt

Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated with calorie restriction. Deletion of FOB1 and overexpression of SIR2 have been previously found to...

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Identifiers

PMID: 15328540
DOI: 10.1371/journal.pbio.0020296
PMCID: PMC514491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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