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Article

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.

Nature - 18 Jul 2002

Lin Su-Ju, Kaeberlein Matt, Andalis Alex A, Sturtz Lori A, Defossez Pierre-Antoine, Culotta Valeria C, Fink Gerald R, Guarente Leonard

Abstract excerpt

Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals. We established a model of CR in budding yeast Saccharomyces cerevisiae. In this system, lifespan can be extended by limiting glucose or by reducing the activity of the glucose-sensing cyclic-AMP-dependent kinase (PKA). Lifespan extension in a mutant with reduced PKA activity...

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Identifiers

PMID: 12124627
DOI: 10.1038/nature00829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.PMID 12124627Read ↗

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.Semantic proximity Read ↗

Extending Healthy Life Span—From Yeast to HumansSemantic proximity Read ↗

An intervention resembling caloric restriction prolongs life span and retards aging in yeast.Semantic proximity Read ↗

Dietary restriction involves <scp>NAD</scp><sup>+</sup>‐dependent mechanisms and a shift toward oxidative metabolismSemantic proximity Read ↗

Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK.Semantic proximity Read ↗

Molecular Links between Caloric Restriction and Sir2/SIRT1 ActivationSemantic proximity Read ↗

Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.Semantic proximity Read ↗

Molecular Mechanisms of Genotype-Dependent Lifespan Variation Mediated by Caloric Restriction: Insight from Wild Yeast IsolatesSemantic proximity Read ↗

Respiratory and TCA cycle activities affect S. cerevisiae lifespan, response to caloric restriction and mtDNA stability.Semantic proximity Read ↗

Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast.Semantic proximity Read ↗

The Dihydrolipoamide Acetyltransferase Is a Novel Metabolic Longevity Factor and Is Required for Calorie Restriction-mediated Life Span ExtensionSemantic proximity Read ↗

Calorie restriction reduces rDNA recombination independently of rDNA silencing.Semantic proximity Read ↗

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