Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation

Abstract excerpt

Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to GABA and Rice Research
• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Sirtuins and Resveratrol in Medicine