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Article

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.

Science (New York, N.Y.) - 22 Sept 2000

Lin S J, Defossez P A, Guarente L

Abstract excerpt

Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may work by reducing the levels of reactive oxygen species produced during respiration, the mechanism by which this regimen slows aging is uncertain. Here, we mimicked calorie restriction in yeast by physiological or genetic means and showed a substantial extension in life-span. This...

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Identifiers

PMID: 11000115
DOI: 10.1126/science.289.5487.2126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.PMID 11000115Read ↗

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Sir2-independent life span extension by calorie restriction in yeast.Semantic proximity Read ↗

Sir2 blocks extreme life-span extension.Semantic proximity Read ↗

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Calorie restriction reduces rDNA recombination independently of rDNA silencing.Semantic proximity Read ↗

Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sir2 mediates longevity in the fly through a pathway related to calorie restriction.Semantic proximity Read ↗

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