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Article

A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae.

G3 (Bethesda, Md.) - 8 Dec 2015

Choy John S, Qadri Bayan, Henry Leah, Shroff Kunal, Bifarin Olatomiwa, Basrai Munira A

Abstract excerpt

Sirtuins are evolutionarily conserved NAD-dependent deacetylases that catalyze the cleavage of NAD(+) into nicotinamide (NAM), which can act as a pan-sirtuin inhibitor in unicellular and multicellular organisms. Sirtuins regulate processes such as transcription, DNA damage repair, chromosome segregation, and longevity extension in yeast and metazoans. The founding member of the evolutionarily conserved sirtuin...

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Source

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Identifiers

PMID: 26646153
DOI: 10.1534/g3.115.022244
PMCID: PMC4751566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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